Ravi Iyengar
Ravi Iyengar, Ph.D., is a systems biologist and Director of the Experimental Therapeutics Institute at the Mount Sinai School of Medicine in New York City, as well as the Dorothy H. and Lewis Rosenstiel Professor and Chairman of the Department of Pharmacology and Systems Therapeutics and Director and Principal Investigator of the NIGMS-funded Systems Biology Center New York at The Mount Sinai Medical Center.[1][2]
Trained as a biochemist, Iyengar studies cellular signaling networks using both experiments and computer simulations. His laboratory focuses on how cell signals are routed and processed through cellular signaling networks within cells to discover new drug targets for complex diseases.[3][4][5] He has published more than 100 primary papers, 92 reviews and is the editor of 6 books.
Biography
Iyengar earned both an undergraduate degree in Chemistry and Physics in 1971 and a master's degree in Biophysics in 1973 from the University of Mumbai in India. He completed his Ph.D. in Biophysical Sciences at the University of Houston in 1977. He joined Baylor College of Medicine in 1977 as a postdoctoral fellow and rose to Assistant and then Associate Professor. In 1986, he joined the Department of Pharmacology at The Mount Sinai Medical Center as an Associate Professor. In 1999, he was appointed Chairman of the Department of Pharmacology at Mount Sinai, and in 2001 he was named Mount Sinai's Dorothy H. and Lewis Rosenstiel Professor and Chair of the Department of Pharmacology and Biological Chemistry.
Iyengar served as the Dean of Research for The Mount Sinai School of Medicine from 2002 to 2004.
In 2004, Iyengar was elected fellow of the American Association for the Advancement of Science.[6] Additional honors include:
Iyengar holds Patent No. 20080261820: Methods to Analyze Biological Networks.[7]
Research grants
- Systems Biology Center in New York, 5P50GM071558-03, National Institute of General Medical Sciences
- Functions of Regulatory Motifs in Signaling Networks, 5R01GM054508-21, National Institute of General Medical Sciences
- Modeling Cell Regulatory Networks, 5R01GM072853-04, National Institute of General Medical Sciences
Books
- Heterotrimeric G Proteins, Volume 237 (Methods in Enzymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, editors. Academic Press; 1st edition (June 28, 1994) ISBN 0121821382
- Heterotrimeric G-Protein Effectors, Volume 238 (Methods in Enymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, Editors. Academic Press; 1st Edition (September 1994) ISBN 0121821390
- G Protein Pathways, Part A: Receptors, Volume 343 (Methods in Enymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 0121822443
- G Protein Pathways, Part B: G Proteins and Their Regulators, Volume 344 (Methods in Enzymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (December 2001) ISBN 0121822451
- G Protein Pathways, Part C: Effector Mechanisms, Volume 345 (Methods in Enzymology). Ravi Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 012182246X
Publications
Partial list:
- Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 7 January 2000;287(5450):142-4. PMID 10615050
- Jordan JD, Landau EM, Iyengar R. Signaling networks: the origins of cellular multitasking. Cell. 13 October 2000;103(2):193-200. PMID 11057893
- Bhalla US, Ram PT, Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science. 9 August 2002;297(5583):1018-23. PMID 12169734
- Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 25 March 2005;280(12):11413-21. PMID 15657046
- Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct. 2005;34:319-49. PMID 15869393
- Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 12 August 2005;309(5737):1078-83. doi:10.1126/science.1108876 PMID 16099987
- Moriarty TM, Sealfon SC, Carty CJ, Roberts JL, Iyengar R, Landau EM. Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin sensitive and insensitive pathways. J. Biol. Chem. 264:13524-13530, 1989. PMID 2474532
- Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J. 1 February 2007;92(3):808-15. PMID 17098795
- Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007 Aug;9(8):858-67. Nat Cell Biol. 2007 Aug;9(8):858-67. PMID 17671451
- Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophys J. 1 April 2008;94(7):2566-79. PMID 18178648
- Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science. 16 May 2008;320(5878):903-9. PMID 18487186
- Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell. 16 May 2008;133(4):666-80. PMID 18485874
- Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science. 15 January 1999;283(5400):381-7. PMID 9888852
- Weng G, Bhalla US, Iyengar R. Complexity in biological signaling systems. Science. 2 April 1999;284(5411):92-6. PMID 10102825
- Jordan JD, Carey KD, Stork PJ, Iyengar R. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. J Biol Chem. 30 July 1999;274(31):21507-10. PMID 10419452
- Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 7 January 2000;287(5450):142-4. PMID 10615050
- Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A. 28 December 2009. PMID 20080566
- Berger SI, Iyengar R. Role of systems pharmacology in understanding drug adverse events. Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr;3(2):129-35. PMID 20803507 PMC PMC3057924
- Rangamani P, Fardin MA, Xiong Y, Lipshtat A, Rossier O, Sheetz MP, Iyengar R. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophys J. 2011 Feb 16;100(4):845-57. PMID 21320428 PMC PMC3037558
- Xiong Y, Rangamani P, Fardin MA, Lipshtat A, Dubin-Thaler B, Rossier O, Sheetz MP, Iyengar R. Mechanisms controlling cell size and shape during isotropic cell-spreading. Biophys J. 2010 May 19;98(10):2136-46. PMID 20483321 PMC PMC2872297
- Berger SI, Ma'ayan A, Iyengar R. Systems pharmacology of arrhythmias. Sci Signal. 2010 Apr 20;3(118):ra30. PMID 20407125 PMC PMC3068558
- Zorina Y, Iyengar R, Bromberg KD. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J Biol Chem. 2010 Jan 8;285(2):1358-70. PMID 19861414 PMC PMC2801262
- Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1247-52. PMID 20080566 PMC PMC2824311
- Berger SI, Iyengar R. Network analyses in systems pharmacology. Bioinformatics. 2009 Oct 1;25(19):2466-72. PMID 19648136 PMC PMC2752618
- Neves SR, Iyengar R. Models of spatially restricted biochemical reaction systems. J Biol Chem. 2009 Feb 27;284(9):5445-9. PMID 18940805 PMC PMC2645809
- Ma'ayan A, Cecchi GA, Wagner J, Rao AR, Iyengar R, Stolovitzky G. Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19235-40. PMID 19033453 PMC PMC2614745
- Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 2008;320(5878):903-9. PMID 18487186 PMC PMC2776723
- Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 2008;133(4):666-80. PMID 18485874 PMC PMC2728678
- Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophys J. 2008 Apr 1;94(7):2566-79. PMID 18178648 PMC PMC2267139
- Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007 Aug;9(8):858-67. PMID 17671451 PMC PMC2735470
- Ma'ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. Mt Sinai J Med. 2007 Apr;74(1):27-32. PMID 17516560 PMC PMC2561141
- Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J. 2007 Feb 1;92(3):808-15. PMID 17098795 PMC PMC1779960
- Ma'ayan A, Lipshtat A, Iyengar R. Topology of resultant networks shaped by evolutionary pressure. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun;73(6 Pt 1):061912. PMID 16906869 PMC PMC3032447
- Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83. PMID 16099987 PMC PMC3032439
- Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct. 2005;34:319-49. PMID 15869393
- Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 2005 Mar 25;280(12):11413-21. PMID 15657046
- Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636-9. PMID 12040175
References
External links
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